(MENAFN- Saudi Press Agency) JACKSONVILLE Fla Dhu-AlQa'dah 11 1436 August 26 2015 SPA -- Researchers at the Mayo Clinic have found a way to turn cancer cells back into normal cells by restoring the balance of key molecules that control certain cellular functions according to a new study UPI reported.
Lab experiments showed the method to successfully reverse the out of control growth of cells that turns them cancerous though researchers said there is no way to know how successful the tactic would be in humans.
"The study brings together two so-far unrelated research fields -- cell-to-cell adhesion and miRNA biology --- to resolve a long-standing problem about the role of adhesion proteins in cell behavior that was baffling scientists" said Dr. Antonis Kourtidis a research associate at the Mayo Clinic in a press release. "Most significantly it uncovers a new strategy for cancer therapy"
Researchers have long thought that 2 adhesion proteins essential to the formation of epithelial tissues E-cadherin and p120 catenin also suppressed the growth of tumors. This turned out to not be true they said because both proteins are present in and required for tumor growth.
Understanding that the proteins play both good and bad roles the researchers thought they could turn them back from the dark side. They discovered that another protein called PLEKHA7 maintains the normal state and growth of cells using micro RNAs or miRNA. When levels of PLEKHA7 drop the miRNAs are misregulated and cadherin and p120 catenin turn from good to bad.
Lab experiments showed the researchers reported in the study that increasing miRNA in cancer cells to normal levels turned the proteins back to good and halted cancer growth.
"By administering the affected miRNAs in cancer cells to restore their normal levels we should be able to re-establish the brakes and restore normal cell function" said Dr. Panos Anastasiadis director of the department of cancer biology at Mayo's Jacksonville campus. "Initial experiments in some aggressive types of cancer are indeed very promising."
The study is published in Nature.
--SPA
02:59 LOCAL TIME 23:59 GMT
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